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Medications and health conditions that can stall weight loss Some medications and health conditions can affect how your body responds to weight loss, even with medication support

These findings are consistent with data accessed on February 9, 2026

This regulates the reaction catalyzing fructose-2,6-bisphosphate (a potent activator of phosphofructokinase-1, the enzyme that is the primary regulatory step of glycolysis) [28] by slowing the rate of its formation, thereby inhibiting the flux of the glycolysis pathway and allowing gluconeogenesis to predominate